AminoTriComplex as an Adjunct to Pemetrexed-Cisplatin in Stage IV Lung Adenocarcinoma

Alexandre Tavartkiladze, Gaiane Simonia, Russel J. Reiter, Ruite Lou, Nana Okrostsvaridze, Dinara Kasradze, Pati Revazishvili, Irine Andronikashvili, Pirdara Nozadze, Givi Tavartkiladze, Rusudan Khutsishvili, Tatia Potskhoraia

Abstract: This prospective, controlled study evaluated the efficacy of AminoTriComplex as an adjunct to standard pemetrexed?cisplatin therapy in adults with stage IV lung adenocarcinoma. Patients received chemotherapy alone or chemotherapy plus AminoTriComplex over three cycles; radiologic assessment at week 9?10 showed higher objective response and disease control rates with the adjunct (ORR 48.7% vs 33.0%; DCR 77.4% vs 56.7%). Translational biomarkers demonstrated consistent modulation of a predefined triad-decreased Survivin, increased Cystatin C, and MT1 re?expression-supporting enhanced apoptotic and circadian signaling. The regimen was well tolerated with no adjunct?attributed grade ≥3 events. These early results suggest that AminoTriComplex may augment first?line chemotherapy efficacy and warrant further evaluation of this multitarget phytotherapeutic approach. Conclusions: In stage IV lung adenocarcinoma, adding AminoTriComplex to pemetrexed?cisplatin was associated with higher early ORR/DCR after three cycles and a triad of biomarker shifts (Survivin↓, Cystatin C↑, MT1↑). These findings support continued evaluation of phytotherapeutic circadian-apoptotic re programming as a complement to chemotherapy and provide a translational monitoring framework for early decision making

Keywords: Nonsmall cell lung cancer, adenocarcinoma, pemetrexed-cisplatin, AminoTriComplex, Survivin, Cystatin C, MT1 (MTNR1A), RECIST, integrative oncology, translational biomarkers

How to Cite?: Alexandre Tavartkiladze, Gaiane Simonia, Russel J. Reiter, Ruite Lou, Nana Okrostsvaridze, Dinara Kasradze, Pati Revazishvili, Irine Andronikashvili, Pirdara Nozadze, Givi Tavartkiladze, Rusudan Khutsishvili, Tatia Potskhoraia, "AminoTriComplex as an Adjunct to Pemetrexed-Cisplatin in Stage IV Lung Adenocarcinoma", Volume 14 Issue 9, September 2025, International Journal of Science and Research (IJSR), Pages: 153-170, https://www.ijsr.net/getabstract.php?paperid=SR25829031604, DOI: https://dx.doi.org/10.21275/SR25829031604