A Spectrum of Low-Grade Appendiceal Mucinous Neoplasms (LAMNs): A Case Series from a Tertiary Care Centre

Dr. Fraishu F J, Dr. Ashley Ann Varughese, Dr. Suma S, Dr. Laila Raji N, Dr. Prema N S

Abstract: Background: Low-grade appendiceal mucinous neoplasms (LAMNs) are rare, enigmatic tumors that often mimic acute appendicitis or adnexal masses due to their nonspecific presentation.1 Early and accurate diagnosis is crucial for preventing complications like pseudomyxoma peritonei. Objectives: To present a case series of three LAMN cases diagnosed within a year, highlighting their varied clinical, radiological, and histopathological spectrum. Methods: This retrospective study includes three patients who underwent appendicectomy or right hemicolectomy following clinical suspicion of appendiceal pathology. Imaging and histopathology were reviewed. Results: All patients presented with right lower quadrant abdominal pain. Radiology suggested mucocele of the appendix in two cases. Gross examination revealed enlarged appendix with mucinous content. Histology confirmed LAMN with extracellular mucin and varying degrees of wall invasion. One case showed mucin pools extending to the serosa. Immunohistochemistry was supportive (SATB2 and CK20 positive, variable CK7). Conclusion: LAMNs are rare and often underdiagnosed preoperatively. Careful pathological examination is essential for accurate diagnosis and optimal surgical management.

Keywords: LAMN, Appendix Tumor, Mucocele, Pseudomyxoma Peritonei

How to Cite?: Dr. Fraishu F J, Dr. Ashley Ann Varughese, Dr. Suma S, Dr. Laila Raji N, Dr. Prema N S, "A Spectrum of Low-Grade Appendiceal Mucinous Neoplasms (LAMNs): A Case Series from a Tertiary Care Centre", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 1365-1367, https://www.ijsr.net/getabstract.php?paperid=SR25824112121, DOI: https://dx.doi.org/10.21275/SR25824112121