Immunohistochemical Evaluation of CD20 Expression in Classical Hodgkin Lymphoma

Faris M Elmahdi1, Nada Abulaban2, Sara M Eloum

Abstract: Classical Hodgkin lymphoma (cHL) is marked by Hodgkin and Reed-Sternberg (HRS) cells that typically lack CD20 expression, although abnormal positivity has been observed. This study aimed to assess CD20 expression in cHL tissues from Western Saudi Arabia using immunohistochemistry. Sixty formalin-fixed paraffin-embedded cHL samples were retrospectively analyzed. CD20 positivity, defined as membranous staining in ?10% of HRS cells, was observed in 23.3% of cases. No significant associations were found with age, gender, or histological subtype. The findings suggest that CD20 expressions are present in a notable subset of cHL cases and highlight the importance of comprehensive immunophenotypic evaluation for accurate diagnosis and potential therapeutic considerations.

Keywords: CD20 expression, Classical Hodgkin lymphoma, Immunohistochemistry, Diagnostic pathology, Saudi Arabia

How to Cite?: Faris M Elmahdi1, Nada Abulaban2, Sara M Eloum, "Immunohistochemical Evaluation of CD20 Expression in Classical Hodgkin Lymphoma", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 198-200, https://www.ijsr.net/getabstract.php?paperid=SR25801113644, DOI: https://dx.doi.org/10.21275/SR25801113644