Azithromycin in Periodontal and Peri-Implant Therapy: A Comprehensive Literature Review

Dr. Alankrita, Dr. Neelesh Singh, Dr. Mohammad Aamir

Abstract: Azithromycin, a macrolide antibiotic with broad medical applications, has also found significant use in dentistry. It's established as a preventive measure against bacterial endocarditis in high-risk dental patients and is employed in treating pertussis and mycobacterial infections. Azithromycin is notably recognized for its minimal likelihood of interacting with other drugs. Its antimicrobial action works by anchoring to the 50S ribosomal subunit, which in turn prevents the synthesis of bacterial proteins. Beyond its antibiotic capabilities, azithromycin has demonstrated efficacy in managing cyclosporin-associated gingival hyperplasia, particularly when administered during the early stages of the condition. Furthermore, its anti-inflammatory and immunomodulatory properties have led some researchers to consider it a 'wonder drug' for periodontal disease management. In this review, the various attributes of azithromycin are analyzed, and clinical research is compiled regarding its role in periodontal treatments, both surgical and non-surgical. This encompasses the management of periodontitis and peri-implantitis, the facilitation of periodontal regeneration, and the treatment of gingival hyperplasia induced by drugs.

Keywords: azithromycin, mechanism of action, periodontitis, peri implantitis, systemic antimicrobials

How to Cite?: Dr. Alankrita, Dr. Neelesh Singh, Dr. Mohammad Aamir, "Azithromycin in Periodontal and Peri-Implant Therapy: A Comprehensive Literature Review", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 1877-1884, https://www.ijsr.net/getabstract.php?paperid=SR25727214847, DOI: https://dx.doi.org/10.21275/SR25727214847