Unraveling the Metabolic Link: A Comprehensive Review of the Interplay Between Diabetes Mellitus and Alzheimer?s Disease

Sameer Thakur

Abstract: Diabetes Mellitus (DM) and Alzheimer?s Disease (AD) are two of the most prevalent chronic conditions worldwide, traditionally studied as distinct entities. However, emerging evidence highlights a strong metabolic and pathophysiological interplay between these disorders. This comprehensive review aims to unravel the metabolic link connecting DM and AD, focusing on insulin resistance, hyperglycemia, inflammation, oxidative stress, and vascular dysfunction as key overlapping mechanisms. We examine clinical and epidemiological studies supporting the increased risk of cognitive decline and AD among diabetic patients, as well as molecular pathways that contribute to neurodegeneration in the diabetic brain. Furthermore, we discuss therapeutic implications, including the potential benefits of anti-diabetic drugs and lifestyle modifications in mitigating AD progression. Understanding this bidirectional relationship is crucial for developing integrated diagnostic and treatment strategies, with the ultimate goal of improving cognitive health in populations burdened by metabolic diseases.

Keywords: Diabetes Mellitus, Alzheimer's Disease, Metabolic Dysfunction Insulin Resistance, Neurodegeneration, Cognitive Decline, Hyperglycemia

How to Cite?: Sameer Thakur, "Unraveling the Metabolic Link: A Comprehensive Review of the Interplay Between Diabetes Mellitus and Alzheimer?s Disease", Volume 14 Issue 8, August 2025, International Journal of Science and Research (IJSR), Pages: 1647-1655, https://www.ijsr.net/getabstract.php?paperid=SR25725113114, DOI: https://dx.doi.org/10.21275/SR25725113114