Clinical and Diagnostic Spectrum of Guillain-Barre Syndrome: A Case Series from a Tertiary Care Centre

Dr. Ravikiran Patil, Dr. Sahana Devadas, Dr. Lakshmi M

Abstract: Background: Guillain-Barre Syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy characterized by rapidly evolving limb weakness, areflexia, and variable sensory and autonomic involvement. Objective: To evaluate the clinical presentation, diagnostic findings, subtypes, and outcomes of GBS patients presenting to a tertiary care hospital. Methods: This retrospective case series included 6 patients diagnosed with GBS at Vani Vilas Hospital. Detailed history, neurological examination, nerve conduction studies (NCS), cerebrospinal fluid (CSF) analysis. GBS was diagnosed using the Brighton criteria and subtyped based on electrophysiological classification. Results: Among 6 patients, the most common presenting symptom was symmetrical limb weakness (83%), with sensory involvement in 16% and cranial nerve palsy in 16%. CSF albumino-cytological dissociation was seen in 83% of cases. The distribution included 50% AIDP, 16% AMAN, 16% AMSAN, and others. Autonomic dysfunction was present in 16%. All patients received IVIG; recovery outcomes were assessed using the GBS disability scale. Conclusion: GBS presents with varied clinical and electrophysiological features. Early diagnosis with NCS and CSF analysis, alongside prompt immunotherapy, leads to favorable outcomes. The study highlights the importance of subtype identification in prognosis and management.

Keywords: Guillain-Barre Syndrome, AIDP, AMAN, Albumino-cytological dissociation, IVIG, Case Series

How to Cite?: Dr. Ravikiran Patil, Dr. Sahana Devadas, Dr. Lakshmi M, "Clinical and Diagnostic Spectrum of Guillain-Barre Syndrome: A Case Series from a Tertiary Care Centre", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 1349-1350, https://www.ijsr.net/getabstract.php?paperid=SR25721163722, DOI: https://dx.doi.org/10.21275/SR25721163722