Haematological Profile in Patients with Decompensated Liver Disease in a Tertiary Care Centre
Abstract: Background: Decompensated liver disease (DLD) is characterised by the liver's inability to perform its normal synthetic and detoxifying functions, leading to systemic complications. Haematological abnormalities are commonly observed in DLD patients, influencing disease progression and patient outcomes. Methods: This is a prospective cohort study conducted at ACS Medical College and Hospital, Chennai, from March 2023 to March 2024. A total of 25 patients aged over 18 years with clinical evidence of decompensated chronic liver disease were included. Patients without signs of decompensation were excluded. Results: Anemia was observed in 100% of patients. Three patients had severe anemia (Hb 1.1 and prolonged PT) was found in 80% (18 males and 2 females), though bleeding manifestations were seen in only 10 patients, with in-hospital bleeding in 2 cases. Leukocytosis was more prevalent than leukopenia and was particularly noted in cases with spontaneous or secondary bacterial peritonitis. Conclusion: Anaemia is the most common haematological abnormality in decompensated liver disease, followed by thrombocytopenia and coagulopathy. While abnormal coagulation profiles were frequent, clinical bleeding was not universal. Haematological monitoring and early intervention are vital in reducing morbidity and mortality in cirrhotic patients.
Keywords: Decompensated liver disease, Haematological profile, leukocytosis, Anaemia in liver disease, Thrombocytopenia, coagulopathy, Prolonged INR, Prothrombin time, Splenomegaly, Cirrhosis
How to Cite?: Dr. N. Ramya Lakshmi, Dr C. Senthil, "Haematological Profile in Patients with Decompensated Liver Disease in a Tertiary Care Centre", Volume 14 Issue 6, June 2025, International Journal of Science and Research (IJSR), Pages: 904-905, https://www.ijsr.net/getabstract.php?paperid=SR25611203934, DOI: https://dx.doi.org/10.21275/SR25611203934