Beyond Bone Pain: Paraparesis as an Unusual Initial Manifestation of Multiple Myeloma

Dr Ankitha N Reddy, Dr Santhosh Gowda H S, Dr Ravi Shankar S N

Abstract: Multiple Myeloma (MM) is a clonal plasma cell malignancy characterized by the overproduction of monoclonal immunoglobulins and complex interactions within the bone marrow microenvironment. It can rarely manifest as neurological disease. We report case of 49 year old female presented with lower limb para paresis and Acute Kidney injury. Investigations revealed renal dysfunction, anaemia, and leucocytosis. Radiology scans revealed Right adnexal mass with lytic lesions of bone. Bone marrow biopsy and aspiration revealed plasma cell disorder. Hence the diagnosis of Multiple Myeloma with Metastatic carcinoma was made and patient was started on chemotherapy. This report highlights the atypical presentation of a common hematological malignancy and emphasizes the need for a comprehensive diagnostic approach in patients with unexplained neurological compromise.

Keywords: Multiple Myeloma, Para paresis, Spinal cord compression, neurological manifestations, AKI