Structural Characterization of Novel 2,2'-(4-(3,4-Dimethoxyphenyl) Pyridine-2,6-diyl) Dithiazole, its Copper Complex and Antioxidant, Antimicrobial and Blood Coagulation Cascade

Madavi Sunitha

Abstract: A novel 2,2'-(4-(3,4-dimethoxyphenyl)pyridine-2,6-diyl)dithiazole (L) and its Copper metal complex [Cu(L)Cl2]. The ligand was prepared by facile one-pot procedure from 2-acetylthiazole and characterized by 1HNMR, 13CNMR, UV-Visible, Mass and Single Crystal XRD. The synthesized compounds were screened for anticoagulant, antiplatelet, antioxidant and antimicrobial studies. Study reveals the anticoagulant nature of synthetic compounds without interfering in the platelet aggregation process. The L and its [Cu(L)Cl2] increased the clotting time of human citrated plasma in both platelet rich plasma and platelet poor plasma. Ligand increases from 180sec to 260 sec and 220sec to 300sec respectively at the concentration of 30?g and its complex is enhanced from the control 180sec to 300sec and 220sec to 340sec respectively at the concentration of 30?g. Fascinatingly, the ligand and its complex did not alter the platelet aggregation process. It is also found that the ligand and its complex exhibit promising antioxidant properties and mild antimicrobial activities. Moreover, the ligand and its complex exhibit non-toxic properties as it cannot rupture the RBC membrane.

Keywords: anticoagulant activity, copper complex, platelet aggregation, antioxidant properties, RBC membrane safety