Transfusion and Laboratory Aspects of CAR-T Cell Therapy: A Pathologist?s Perspective on T Lymphocyte Collection, Transport, and Infusion

Dr. Anubhuti Jain, Dr. Joyce Regi

Abstract: Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized treatment options for relapsed/refractory hematologic malignancies. This article describes the transfusion and laboratory processes associated with a CAR-T therapy case from the viewpoint of a pathologist. Our centre was responsible for the leukapheresis collection of autologous T lymphocytes using the COM. TEC system, with subsequent transport to a processing facility and infusion of the CAR-T product after it was processed. The study highlights the critical roles of cell collection protocols, quality assurance during transport, and laboratory coordination in ensuring a successful outcome.

Keywords: CAR-T cell therapy, T lymphocyte collection, leukapheresis, transfusion medicine

How to Cite?: Dr. Anubhuti Jain, Dr. Joyce Regi, "Transfusion and Laboratory Aspects of CAR-T Cell Therapy: A Pathologist?s Perspective on T Lymphocyte Collection, Transport, and Infusion", Volume 14 Issue 5, May 2025, International Journal of Science and Research (IJSR), Pages: 923-925, https://www.ijsr.net/getabstract.php?paperid=SR25512114105, DOI: https://dx.doi.org/10.21275/SR25512114105