Comparative Evaluation of the Clinical Efficacy Between Hyaluronic Acid and Chlorhexidine Mouthwash on Dental Plaque and Gingival Inflammation in Adults - A Systematic Review

Dr. Shushrusha Shirsat, Dr. Akshaya Banodkar, Dr. Rajesh Gaikwad, Dr. Harshda Mahajan

Abstract: Background: This systematic review investigated the antiplaque and anti-inflammatory effects of CHX and HA mouthwashes. Aim: To compare the clinical efficacy between Hyaluronic acid & chlorhexidine mouth wash on dental plaque and gingival inflammation. Materials And Methods: A comprehensive search of the following search engine was performed, namely: PubMed, Cochrane, Google Scholar. A systematic search of PubMed was done. The keywords for the search included "chlorhexidine mouthwash" OR " AND "HA mouthwash" "gingivitis" "periodontitis". For Cochrane and google scholar similar strategy was used. All the search was limited to articles in English language. Results: 4 randomized controlled trails, double blinded which met the inclusion criteria covering 248 participants used chlorhexidine and hyaluronic acid mouthwash. 1 study was crossover clinical study. Conclusion: HA is as effective as CHX. In addition, based on its better acceptance by the participants, HA is potentially a good alternative to CHX, with higher effect of hyaluronic acid (HA) on plaque and gingival index.

Keywords: Chlorhexidine, hyaluronic acid, gingivitis, periodontitis, plaque, gingival inflammation