Comparative Evaluation of the Clinical Efficacy Between Hyaluronic Acid and Chlorhexidine Mouthwash on Dental Plaque and Gingival Inflammation in Adults - A Systematic Review

Dr. Shushrusha Shirsat, Dr. Akshaya Banodkar, Dr. Rajesh Gaikwad, Dr. Harshda Mahajan

Abstract: Background: This systematic review investigated the antiplaque and anti-inflammatory effects of CHX and HA mouthwashes. Aim: To compare the clinical efficacy between Hyaluronic acid & chlorhexidine mouth wash on dental plaque and gingival inflammation. Materials And Methods: A comprehensive search of the following search engine was performed, namely: PubMed, Cochrane, Google Scholar. A systematic search of PubMed was done. The keywords for the search included "chlorhexidine mouthwash" OR " AND "HA mouthwash" "gingivitis" "periodontitis". For Cochrane and google scholar similar strategy was used. All the search was limited to articles in English language. Results: 4 randomized controlled trails, double blinded which met the inclusion criteria covering 248 participants used chlorhexidine and hyaluronic acid mouthwash. 1 study was crossover clinical study. Conclusion: HA is as effective as CHX. In addition, based on its better acceptance by the participants, HA is potentially a good alternative to CHX, with higher effect of hyaluronic acid (HA) on plaque and gingival index.

Keywords: Chlorhexidine, hyaluronic acid, gingivitis, periodontitis, plaque, gingival inflammation

How to Cite?: Dr. Shushrusha Shirsat, Dr. Akshaya Banodkar, Dr. Rajesh Gaikwad, Dr. Harshda Mahajan, "Comparative Evaluation of the Clinical Efficacy Between Hyaluronic Acid and Chlorhexidine Mouthwash on Dental Plaque and Gingival Inflammation in Adults - A Systematic Review", Volume 14 Issue 4, April 2025, International Journal of Science and Research (IJSR), Pages: 1154-1157, https://www.ijsr.net/getabstract.php?paperid=SR25415193853, DOI: https://dx.doi.org/10.21275/SR25415193853