Comparison of Ovulation Induction Protocols in Non-IVF Cases

Dr. Bharti Maheshwari, Dr. Preeti Sharma, Dr Maheeb Rehman

Abstract: Introduction: Ovulation induction (OI) is critical in treating anovulation, often associated with conditions like polycystic ovary syndrome (PCOS) and hypothalamic amenorrhea, which can lead to infertility. OI aims to stimulate egg production, enhancing conception chances without necessitating in vitro fertilization (IVF). Protocols vary by diagnosis and medication type, with a focus on improving effectiveness and reducing side effects through protocol compression, which shortens treatment duration and reduces cycles. Aim and Objectives: Aim: To assess the effectiveness of different ovulation induction protocols in enhancing fertility among women undergoing non - IVF treatments. Objectives: To evaluate the rates of successful ovulation, conception, and pregnancy across various OI protocols. Methodology: This multicenter, prospective cohort study involved women aged 18 - 40 with anovulatory infertility, using a stratified design across treatments: Clomiphene Citrate, Letrozole, and Gonadotropins. Outcomes measured were ovulation, conception, and pregnancy rates, with secondary outcomes including multiple pregnancies and treatment - related complications. Results and Conclusion: Results showed Gonadotropins had the highest clinical pregnancy rate at 70%, followed by Letrozole (52%) and Clomiphene Citrate (44%). The study confirmed significant differences in pregnancy outcomes across the protocols (p - value = 0.018**), highlighting Gonadotropins as the most effective. This study supports the strategic selection of OI protocols based on their efficacy in non - IVF reproductive treatments.

Keywords: Ovulation Induction, Anovulation, Infertility Treatment, Non - IVF Reproductive Treatments, Clomiphene Citrate, Letrozole, Gonadotropins, Clinical Pregnancy Rates, Protocol Efficiency