Role of the Transfusion Medicine Department in Abo- Incompatible Renal Transplantation: A Case Study in a Government Tertiary Care Hospital

Dr. Mangaiyarkarasi Amirthalingam, Dr. Senthil

Abstract: The Transfusion Medicine and Apheresis team play a crucial role in ABO-incompatible (ABO-I) renal transplantation by mitigating the immunological challenges associated with blood group incompatibility. This case study details the pre-transplant therapeutic plasma exchange (TPE), ABO antibody titration, intraoperative and postoperative management and blood component therapy. The study highlights how an established Transfusion Medicine Department facilitates complex procedures such as ABO-I renal transplantation in Government tertiary care hospitals. Additionally, it presents clinical findings from a specific case and reviews relevant literature on the topic.

Keywords: ABO- incompatible renal transplantation, Therapeutic plasma Exchange, transfusion medicine, desensitization protocol, immunosuppressive therapy