Successful Non-Surgical Endodontic Treatment of Large Periapical Lesions using Platelet-Rich Fibrin and Mineral Trioxide Aggregate: Clinical Trial with Cone Beam Computed Tomography Evaluation

Randa Farag Salih, Ashraf M. Elmansori, Sara Momamed A. M. Bogazia, Ghada Gehani, Abdulla Y. Hamd. Mohamed, Anas Elharathi

Abstract: Plasma-Rich Fibrin (PRF) is a novel regenerative approach in dentistry, particularly for the treatment of periapical lesions. This study evaluates the effectiveness of PRF combined with Mineral Trioxide Aggregate (MTA) in non-surgical endodontic treatment. A clinical trial was conducted involving 35 patients with diagnosed periapical lesions, monitored over six months using Cone Beam Computed Tomography (CBCT). The results showed a significant healing rate, with 60% of cases achieving complete lesion resolution. The study concludes that PRF, when combined with MTA, is an effective treatment for periapical bone lesions, highlighting the importance of CBCT follow-ups for long-term assessment.

Keywords: Platelet-Rich Fibrin, CBCT, Periapical Lesions, Endodontic Healing, Mineral Trioxide Aggregate