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Analysis Study Research Paper | General Surgery | India | Volume 14 Issue 2, February 2025 | Popularity: 5.3 / 10
Clinical and Treatment Profile with Five Year Survival Analysis of Colorectal Cancer <50 Years from Northern India
Kaushal Singh Rathore, U. K Chandel, Niharika Singh
Abstract: Background: The incidence of colorectal cancer (CRC) has been increasing worldwide. Middle- and low-income countries are also experiencing increases in these cases. This is attributed to their large and rapidly growing populations coupled with the adoption of westernized diets and lifestyles. Methods: All diagnosed cases of colorectal cancer presenting to IGMC Shimla (the sole tertiary cancer care center in the state of Himachal Pradesh, India) between January 2017 and December 2018 were included. Data on the clinical characteristics, pathology, treatment received, and survival outcomes were recorded. A follow-up period of 60 months (last follow-up 31st December 2023) was recorded. Results: The study included 55 patients, with a male predominance, and 34% were aged <50 years. The most prevalent symptoms were anorexia and weight loss (98%), with the rectum being the most common site (45%). Histopathological signet ring-type morphology was observed in 27% of cases, and the majority of patients presented with advanced stages III (34%) and IV (30%). Radiation oncologists, surgeons, and medical oncologists use multimodal treatment approaches. After 60 months of follow-up, seven patients were lost to follow-up and only six remained alive, with a mean survival of 39 months. Conclusion: Most patients presented at an advanced stage with a significantly young population, which not only resulted in complex management, but also poor survival outcomes. Further epidemiological studies, including genetic analyses, are necessary to characterize the presentation of colorectal cancer in our state.
Keywords: Colorectal cancer in young patients, clinicopathological and treatment profiles, follow-up, multimodality treatment
Edition: Volume 14 Issue 2, February 2025
Pages: 217 - 220
DOI: https://www.doi.org/10.21275/SR25201183556
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