Microwave Assisted Synthesis and Characterization of 2,7-(substitutedphenyl)-3-phenyl-2,3,7,7a-tetrahydrothiazolo[4,5-d]pyrimidin-5(6H)- One Derivatives

Dr. Gauri P. Deshpande, Dr. S. P. Shahare, Y. D. Bansod

Abstract: Microwave assisted synthesis of thiazolopyrimidine derivatives is economic, convenient and environment friendly method of synthesis. In Scientific microwave oven the rate of reaction enhance due to polarization of molecules. In this reaction, 2,3-substitutedphenylthiazolodin-4-one(0.01M), aromatic aldehyde (0.015M) and urea(0.01M) in presence of pyridine catalyst and DMSO solvent undergo condensation reaction on microwave irradiation for 2-2.5 minutes, synthesized 2,7-(substitutedphenyl)3-phenyl-2,3,7,7a-tetrahydrothiazolo[4,5-d]pyrimidin-5(6H)-one. -The targeted compounds were analysed by IR, NMR, CMR Spectrum and CHNS elemental detection. Melting point are uncorrected and carried out on Thieles apparatus.

Keywords: Thiazolidin-4-one-, 2,7-(substitutedphenyl)3-phenyl-2,3,7,7a-tetrahydrothiazolo[4,5-d]pyrimidin-5(6H)-one, microwave irradiation.

How to Cite?: Dr. Gauri P. Deshpande, Dr. S. P. Shahare, Y. D. Bansod, "Microwave Assisted Synthesis and Characterization of 2,7-(substitutedphenyl)-3-phenyl-2,3,7,7a-tetrahydrothiazolo[4,5-d]pyrimidin-5(6H)- One Derivatives", Volume 14 Issue 12, December 2025, International Journal of Science and Research (IJSR), Pages: 2258-2260, https://www.ijsr.net/getabstract.php?paperid=SR251226151550, DOI: https://dx.doi.org/10.21275/SR251226151550