Genetic Influences on Anesthetic Drug Response: Pharmacogenomic Considerations for Personalized Anesthesia
Abstract: Genetic variations significantly influence how individuals respond to anesthetic agents, affecting drug efficacy, metabolism, and safety. Pharmacogenetics examines these genetic factors and guides anesthetic decisions to minimize adverse reactions. This review highlights key genetic polymorphisms that alter the pharmacokinetics and pharmacodynamics of commonly used anesthetic drugs. It also explores the growing role of precision medicine, bioinformatics tools, and machine learning in tailoring anesthesia plans. Integrating pharmacogenomic insights into clinical practice enhances patient safety, optimizes outcomes, and represents the future direction of personalized anesthesia care. (1, 2, 3, 4, 5, 6, 7, 8)
Keywords: Genetics, pharmacogenomics, anesthesia, mutations, polymorphism
How to Cite?: Dr. Chandra Sekhar Krishna Murti, "Genetic Influences on Anesthetic Drug Response: Pharmacogenomic Considerations for Personalized Anesthesia", Volume 14 Issue 12, December 2025, International Journal of Science and Research (IJSR), Pages: 228-231, https://www.ijsr.net/getabstract.php?paperid=SR251128052444, DOI: https://dx.doi.org/10.21275/SR251128052444