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Comparative Studies | Dermatology | Volume 14 Issue 11, November 2025 | Pages: 1734 - 1736 | India
Comparative Evaluation of Q-Switched Nd:YAG Laser and 50% Glycolic Acid Peel in Melasma: A Prospective Interventional Study
Abstract: Background: Melasma is a chronic, relapsing hyperpigmentation disorder that significantly affects quality of life, especially in individuals with intermediate-to-dark skin types. Procedures like glycolic acid peels and Q-switched Nd:YAG lasers are valuable treatment options, but comparative evidence in Indian patients remains limited. Aim: To compare the efficacy, safety, and tolerability of Q-switched Nd:YAG laser with 50% glycolic acid peel in the treatment of melasma. Methods: In this prospective interventional study, 60 clinically diagnosed melasma patients were randomized into two groups of 30 each: one receiving 50% glycolic acid peels and the other Q-switched Nd:YAG laser therapy. Treatments were administered every 4 weeks for 5-6 sessions in the peel group and 4-5 sessions in the laser group. Standardized MASI scoring, dermoscopic evaluation, and photographic documentation were performed at baseline and at 4-week intervals up to 24 weeks. Results: Both modalities demonstrated statistically significant reductions in MASI scores over 24 weeks (p
Keywords: Melasma, Glycolic acid peel, Q-switched Nd:YAG laser, Hyperpigmentation, MASI score
How to Cite?: Dr. Isha Gupta, Dr. Vishal V. Wali, Dr. Kiran S. Malipatil, Dr. Shristi Reddy, Dr. Abhishek Patil, "Comparative Evaluation of Q-Switched Nd:YAG Laser and 50% Glycolic Acid Peel in Melasma: A Prospective Interventional Study", Volume 14 Issue 11, November 2025, International Journal of Science and Research (IJSR), Pages: 1734-1736, https://www.ijsr.net/getabstract.php?paperid=SR251125222950, DOI: https://dx.doi.org/10.21275/SR251125222950