Application of Sintering Technique for Development and In-vitro Characterization of Repaglinide Sustained Release Matrix Tablets

Latha Kukati, Navya Sri, Aisha Rahman, G. Sowmya Varma M. Rohini, Mohd Mohsin

Abstract: The current study attempted to develop repaglinide sustained release matrix tablets using ethyl cellulose as release retarding material. Repaglinide is an oral antihyperglycemic agent used for the treatment of Type II diabetes mellitus. Repaglinide belongs to a BCS class II drug having low solubility & high permeability. This drug was approved by FDA in 1997. It has half-life of 1hr. This drug is given 3-4 times per day. Due to its shorter half-life and rapid onset of action it serves as good candidate for preparing sustained release matrix tablets. Furthermore the prepared sustained release matrix tablets were subjected to chemical sintering technique, where acetone vapours were used to increase cross linkage within the polymeric structure. The tablets so designed were within the acceptable range of physicochemical properties. Formulation F10 containing ethyl cellulose, was subjected to acetone vapours up to 8 hrs has shown better dissolution profile of 93.1% in 9hrs. Hence, F10 formulation was chosen as final optimized formulation. The in-vitro release data was considered for curve fitting mathematical equations and was concluded with zero order kinetics with anomalous transport mechanism. The results lead to the conclusion that sustained release sintered tablets of repaglinide having ethyl cellulose provides a preferable option for sustaining the drug release with low concentration of hydrophobic polymer for an extension of 9 hrs.

Keywords: Solubility, Repaglinide, Sustained release, Ethyl cellulose

How to Cite?: Latha Kukati, Navya Sri, Aisha Rahman, G. Sowmya Varma M. Rohini, Mohd Mohsin, "Application of Sintering Technique for Development and In-vitro Characterization of Repaglinide Sustained Release Matrix Tablets", Volume 14 Issue 11, November 2025, International Journal of Science and Research (IJSR), Pages: 363-372, https://www.ijsr.net/getabstract.php?paperid=SR251104112127, DOI: https://dx.doi.org/10.21275/SR251104112127