Green Iodine Mediated Thiolation of Indole Derivatives: A Review

Deepak Sharma, Abha Chaudhary

Abstract: Indole derivatives represent a pivotal class of heterocyclic compounds with broad applications in pharmaceuticals, agrochemicals, and materials science. The development of efficient, selective, and environmentally benign synthetic methodologies for their functionalization remains a central focus in organic chemistry. Iodine-based reagents, particularly molecular iodine and hypervalent iodine (III) species, have emerged as versatile and sustainable tools in this domain. This review highlights recent advances in the synthesis and functionalization of indole scaffolds using iodine reagents, emphasizing their role in C?H activation, oxidative coupling, halogenation, and cyclization reactions. The mild reaction conditions, high regioselectivity, and eco-friendly nature of iodine-mediated protocols underscore their growing significance in modern synthetic strategies. In this review paper, we want to draw attention to the important developments in molecular iodine-catalyzed/promoted reactions of indole for C-S bond formation i.e. thiolation of indole that have occurred since 2014 for chemistry researchers.

Keywords: Indole, Iodine catalysis, Thiolation, Green

How to Cite?: Deepak Sharma, Abha Chaudhary, "Green Iodine Mediated Thiolation of Indole Derivatives: A Review", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 1390-1398, https://www.ijsr.net/getabstract.php?paperid=SR251024145338, DOI: https://dx.doi.org/10.21275/SR251024145338