Dual Action Defense - An In Vivo Assessment of Salivary Fluoride Dynamics Post Fluoride Varnish-Povidone Iodine Application

Dr. Sneha S, Dr. Krishnamoorthy S. H, Dr. Savitha Sathyaprasad

Abstract: Background: Fluoride varnish is widely used as a caries-preventive agent due to its ability to enhance enamel remineralization and inhibit demineralization. The adjunctive use of Povidone-Iodine (PVP-I), a broad-spectrum antimicrobial, may prolong fluoride retention in the oral cavity by reducing cariogenic bacterial activity. Aim: To estimate salivary fluoride concentration following topical application of fluoride varnish with Povidone-Iodine at different time intervals. Materials and Methods: Fifteen healthy children aged 7?10 years were enrolled. After baseline unstimulated saliva collection, PVP-I was applied for one minute and rinsed off, followed by application of fluoride varnish. Saliva samples were collected at baseline, 24 hour and 48 hours. Fluoride concentration was estimated using a fluoride ion-specific electrode. Data were analyzed using repeated measures ANOVA (p < 0.05). Results: Mean baseline fluoride level was 0.35 ppm. Following FV + PVP-I application, fluoride levels rose significantly at 24 hours (1.65 ppm), gradually decreased at 48 hours (1.32 ppm). The rise at 24 h and 48 h compared to baseline was statistically significant (p < 0.05). Conclusion: Application of fluoride varnish with Povidone-Iodine significantly elevated salivary fluoride concentration for up to 48 hours. This combination may provide dual benefits of antibacterial action and enhanced fluoride availability, supporting its use as a preventive strategy in Pediatric dentistry.

Keywords: fluoride varnish, povidone-iodine, salivary fluoride concentration, enamel remineralization, pediatric dentistry

How to Cite?: Dr. Sneha S, Dr. Krishnamoorthy S. H, Dr. Savitha Sathyaprasad, "Dual Action Defense - An In Vivo Assessment of Salivary Fluoride Dynamics Post Fluoride Varnish-Povidone Iodine Application", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 188-189, https://www.ijsr.net/getabstract.php?paperid=SR251002121947, DOI: https://dx.doi.org/10.21275/SR251002121947