EGFR Mutations, ROS1 and ALK Rearrangements, Smoking and Gender Association in Non?Small Cell Lung Cancer Patients at a Tertiary Care Centre in South India
Abstract: Background: Driver mutations show up in about 80% lung adenocarcinomas. They play big role in treatment choices & how well patients do. Aim: This study looks at how often we see mutations in the epidermal growth factor receptor (EGFR), well as ALK & ROS1 changes. We also checked how these relate to age & gender in non - small cell lung cancer. Plus, we wanted to see how smoking affects EGFR mutations. This info comes from a medical center in South India. Methods: We included everyone aged 20 - 80 who was diagnosed with lung cancer & treated at Government Rajaji Hospital in Alwarpuram, Madurai, Tamil Nadu, between June 2023 and September 2024. This was a descriptive and cross - sectional study based on past records. Results: From the 90 patients with confirmed lung cancer, 61 (67.77%) were men & 29 (32.22%) were women. A total of 74 patients (82.22%) had adenocarcinoma, while 16 patients (17.77%) had squamous cell carcinoma. Among the study group, 23 patients (25.5%) had detected EGFR mutations, 3 (3.33%) had ALK mutations, & only 1 patient (1.11%) had a ROS1 mutation. Also, one patient each had positive results for ALK & ROS1 mutations (2.32%). In those with EGFR mutations, 15 patients (65.21%) were men, and 8 (34.78%) were women. Notably, only a small number of smokers had EGFR mutations - 30.43% (7 patients) compared to 69.5% (16 patients) who didn?t smoke. Conclusion: This study gives us important insights into lung cancer patterns among people in Tamil Nadu.
Keywords: Lung cancer, EGFR mutations, ALK mutations, smoking, Tamil Nadu
How to Cite?: Dr. Lingeshwaran S, Dr P N Rajasekaran, Dr Jebasingh, "EGFR Mutations, ROS1 and ALK Rearrangements, Smoking and Gender Association in Non?Small Cell Lung Cancer Patients at a Tertiary Care Centre in South India", Volume 13 Issue 9, September 2024, International Journal of Science and Research (IJSR), Pages: 862-864, https://www.ijsr.net/getabstract.php?paperid=SR24914001755, DOI: https://dx.doi.org/10.21275/SR24914001755