Comparison of Cardioprotective Effects of Sevoflurane versus Propofol in Patients of Aneurysmal Subarachnoid Haemorrhage - Single Blind Randomized Clinical Study
Abstract: Background: Volatile anaesthetic agents have shown myocardial protective effects on heart and its use may show long term cardio - protective effects in immediate postoperative period. Therefore, this study aims to compare the cardio - protective role of sevoflurane MAC - 2 and sevoflurane MAC - 2.5 versus propofol during aneurysm clipping surgery in patients of subarachnoid haemorrhage SAH. Methods: A total of 90 patients aged 18 - 60 years undergoing clipping for aneurysmal SAH were included in the study. The patients were randomized using sealed - envelope technique into three groups of 30 each. Group 1 - Propofol (1 - 1.5 mg/kg) intravenous, Group 2 & Group 3 - Patients inhaled Sevoflurane. In group - 2, MAC was maintained at 2 and in group 3 MAC was maintained at 2.5. Blood samples were collected from patient before induction of anaesthesia, after surgery, and at 48 hrs post - surgery to detect cardiac injury markers troponin I, CK - MB and BNP levels. Continuous variables with normal distribution were compared between groups using one - way ANOVA, while continuous variables not normally distributed were compared using the Kruskal - Wallis test. The categorical data was analysed using Fischer - Exact test. P - value
Keywords: Sevoflurane, Propofol, Cardioprotective, Subarachnoid Hemorrhage, Aneurysm Clipping
How to Cite?: Supriya, Deep Shikha, Madhulika Dubey, "Comparison of Cardioprotective Effects of Sevoflurane versus Propofol in Patients of Aneurysmal Subarachnoid Haemorrhage - Single Blind Randomized Clinical Study", Volume 13 Issue 8, August 2024, International Journal of Science and Research (IJSR), Pages: 17-22, https://www.ijsr.net/getabstract.php?paperid=SR24729211950, DOI: https://dx.doi.org/10.21275/SR24729211950