Biological Study of Some Newly Photo Induced Acridinium Catalyzed, Synthesized Spiro - Cyclic Pyrazolone Derivatives

Vijay Pratap Singh, Amrendra Kumar Singh, Shailendra Singh

Abstract: The objective of this study was evaluation of biological activity of (3a - 3n) spiro - pyrazolones, synthesized by visible light mediated organo - photo redox acridinium catalysis. This examination by single spore isolation and disc diffusion method shows that all compounds have antimicrobial activity. The compounds 3l, 3m shows best antibacterial activity against Gram positive bacteria Staphylococcus aureus, Bacillus subtilis, Gram negative bacteria Pseudomonas aeruginosa, Escherichia coli and antifungal activity against Aspergillus niger.

Keywords: Spiro - pyrazolones, Antibacterial activity, Inhibition zones, Single spore isolation, Disc diffusion