Comparative Study of Immune Activation and Inflammatory Markers IL-6 and IL-4 in HIV Patients

Priyanka, Dr. R. K. Vyas, Dr. Dharam Veer Sihag, Dr. B. L. Meena

Abstract: HIV Human Immunodeficiency Virus significantly impacts the immune system, leading to AIDS Acquired Immune Deficiency Syndrome. This study evaluates the levels of inflammatory markers IL-6 and IL-4 in HIV patients. It was an observational case-control study conducted at the Department of Biochemistry and General Medicine ART Unit Sardar Patel Medical College Bikaner, Rajasthan. Fifty HIV patients and fifty healthy controls were included. The study analyzed serum interleukins IL-6 and IL-4. Results showed significantly higher levels of IL-6 and IL-4 in newly diagnosed HIV ART-nave patients compared to follow-up patients after one year of ART treatment and healthy subjects. The findings indicate that IL-6 and IL-4 levels could be used in combination with CD4 counts to monitor disease progression and treatment efficacy.

Keywords: HIV, Interleukins, Inflammatory Markers, IL-6, IL-4