Histoplasma: The Great Mimicker

Ojas Unavane, Ashutosh Tiwari, N. R. Shetty, Sumeet Singhania

Abstract: We present a case of histoplasmosis that was initially misdiagnosed as malignancy and viral infection before being incidentally diagnosed. Histoplasmosis can mimic various diseases, making its diagnosis challenging. Key clues include the patient being from an endemic area, being immunocompromised, or having exposure to potential sources (e. g., bats in caves). In our case, none of these risk factors were present. The unique presentation as a cobblestone larynx further complicated the diagnosis. This case underscores the importance of recognizing histoplasmosis, even in atypical presentations, to enhance awareness and ensure timely treatment.

Keywords: Histoplasma, Cobblestone larynx, biopsy