Squamous Cell Carcinoma Sinonasal: A Case Report

Dr. Made Diah Ari Bestari, Dr. R. Yully Prapyatiningsih

Abstract: Introduction: Squamous cell carcinoma (SCC) of the nasal and paranasal sinuses (SNSCC) is the most common histologic subtype of all sinonasal tumors. It arises from mucosal sites throughout the paranasal sinuses, namely nasal cavity to maxillary sinus. Preoperative histologic diagnosis of a given sinonasal lesion is essential to correctly plan a proper treatment strategy. Multimodality therapy regimens, including surgery, radiotherapy (RT), and/or chemotherapy, are frequently utilized in the treatment of these tumors. Case report: A 43rd years old male, came to the ENT outpatient department with a chief complain of a mass on the nose since one and a half years before. He was diagnosed with SCC sinonasal stage IVA, after a tumor biopsy. He was scheduled for chemotherapy at April 8th 2024 with Paclitaxel 270 mg and Carboplatin 690 mg and scheduled for the second chemotherapy at April 30th 2024. Discussion: SNSCC is a complex disease, and its pathogenesis is poorly understood. Histologic diagnosis of SNSCCs can be challenging due to relative rarity, a large miscellany of different possible histology, and overlapping appearance of other malignancy or inflammatory disease. Surgery is a potentially curative treatment for resectable SNSCC. To achieve negative surgical margins, the use of induction chemotherapy has been investigated as part of multimodal treatment.

Keywords: sinonasal, squamous cell carcinoma, SCC, SCC sinonasal