An Investigation into the Preanalytical and Analytical Factors Influencing the Determination of the Erythrocyte Sedimentation Rate

Sreeganesh A S, Athulya Krishnan B

Abstract: This study aims to evaluate the variation in Erythrocyte Sedimentation Rate (ESR) due to various preanalytical and analytical factors. The preanalytical variables examined include the anticoagulant to blood ratio, storage time of blood samples(refrigerated), and the tilt angle of the ESR tube. Additionally, the impact of time delay between blood collection and ESR determination is analyzed. By systematically assessing these factors, the study seeks to identify critical variables that influence ESR measurements, thereby enhancing the accuracy and reliability of ESR as a diagnostic tool. The findings are expected to provide valuable insights for standardizing ESR testing protocols and minimizing potential errors in clinical settings.

Keywords: Erythrocyte Sedimentation Rate, anticoagulants, storage time, tilt angle