Chimeric Antigen Receptors T Cells (CAR T) Therapy

Yuvraj Singh

Abstract: Chimeric antigen receptors T cells (CAR T) therapy represents a revolutionary approach to cancer treatment. Utilizing the power of immune system to target and eliminate malignant cells. The studies included were reviewed from PubMed, cancer. net, cancer. gov, clinical trials. gov, web of science. Through genetic engineering, T cells are modified to express chimeric antigen receptors, enabling them to recognize and attack specific antigens present on cancer cells. The positive result of CAR - T therapy in treating hematologic malignancies, such as ALL acute lymphoblastic leukemia and non - Hodgkin lymphoma, has been remarkable. However, complications remain, including the management of CAR - T cell infusion - related effects such as cytokine release syndrome and neurotoxicity, as well as the growth of resistance mechanisms in some cases.

Keywords: chimeric antigen receptor T cell, response, side effect, relapse, analysis