Evaluation of C Reactive Protein Levels with Reference to Clinical Suspicion of Appendicitis

Dr. Aakash Kanago, Dr. Ashwinee Deotale

Abstract: C reactive protein is an acute phase reactant protein expressed in hepatocytes in response to inflammation, bacterial infection, trauma, necrosis of tissues and malignancy. The aim of this study is establish the correlation of CRP in clinically suspicious appendicitis. The study consisted of 100 patients who underwent appendicectomy for the treatment of appendicitis. Biopsies of all these patients sent to histopathology were examined. The test was found to have a sensitivity of 85.71%, specificity of 78.26% with PPV of 92.95% and NPV of 62.06%. It was concluded that elevated CRP levels can confirm surgical indication of appendicitis confirmed with clinical signs and symptoms and ultrasonography. It can be used as an adjuvant to reduce complication rate and avoid negative laparotomies.

Keywords: C reactive protein, appendicitis, appendicectomy