Synthesis of Different Derivatives of Pyrido[1,2-a] Pyrimidine and Evaluation of their Antioxidant Activities

Avinash V Pawde

Abstract: The reaction of 2-amino-5-bromopyridine (1) with ethyl 2-cyano-3,3-bis(methylthio)acrylate (2) in N, N-dimethylformamide (DMF) in the presence of anhydrous potassium carbonate afforded 7-bromo-3-cyano-4-oxo-2-(methylthio)-4H-pyrido[1,2-a] pyrimidine (3). The synthesized pyrido[1,2-a] pyrimidine derivative was subsequently subjected to nucleophilic substitution reactions with various substituted aromatic amines and phenols to obtain a series of 7-bromo-3-cyano-4-oxo-2-(substituted)-4H-pyrido[1,2-a]pyrimidine derivatives.

Keywords: Pyrido[1,2-a] pyrimidine, ethyl 2-cyano-3,3-bis(methylthio)acrylate, N, N-dimethylformamide, nucleophilic substitution

How to Cite?: Avinash V Pawde, "Synthesis of Different Derivatives of Pyrido[1,2-a] Pyrimidine and Evaluation of their Antioxidant Activities", Volume 13 Issue 4, April 2024, International Journal of Science and Research (IJSR), Pages: 2026-2028, https://www.ijsr.net/getabstract.php?paperid=SR24415093749, DOI: https://dx.doi.org/10.21275/SR24415093749

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