International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




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Research Paper | Histopathology | Saudi Arabia | Volume 13 Issue 4, April 2024 | Rating: 6.8 / 10


Detection of Micronuclei in Oral Mucosa among Saudi Smokers Using Papanicolaou Stain

Faris M. Elmahdi | Amina J. Alshinqiti | Jori O. Kareembakhsh | Hanadi A. Alahmadi | Abdullah A. Bakkari | Raghad A. Murad | Sara M. Altom


Abstract: Background: The presence of micronuclei in oral epithelial cells is considered a marker of genotoxicity, which can be identified using exfoliative cytology. Objective: To investigate the presence of micronuclei in the oral mucosa of Saudi smokers using the Papanicolaou stain technique, and to compare these findings with non - smokers. Materials and methods: We conducted a cross - sectional study in KSA from May to October 2023. We collected cytologic oral smear samples from 200 volunteers, of which 100 were smokers and the remaining 100 were non - smokers. We then stained them using the Papanicolaou staining procedure to detect the presence of micronuclei. Results: The mean micronuclei values per 1000 cells were 3.8 ? 1.09 for smokers and 1.85 ? 1.04 for nonsmokers. Smokers had significantly higher values of micronucleated cells compared to nonsmokers, Conclusion: We concluded that the micronuclei count can be used as an early indicator for alterations of oral mucosa and exfoliative cytology represents an accessible tool which could be applied for mass screening.


Keywords: Micronuclei, Oral Mucosa, Papanicolaou Stain


Edition: Volume 13 Issue 4, April 2024,


Pages: 1058 - 1062



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