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Research Paper | Biological Sciences | India | Volume 13 Issue 4, April 2024
ABO Blood Group and Osteoarthritis: A Predominant Phenomenon
Poulomi Das | Dr. Suparna Sanyal Mukherjee | Dr. Pranabesh Ghosh
Abstract: Human ABO blood type antigens exhibit alternative phenotypes and genetically derived glycoconjugate structures that used to be located on the red cell surface which play a vital role in the cells' physiology and pathology. In this context blood type and disease have been studied since the early 1900s when study determined that antibodies and antigens are inherited. However, due to lack of antigens of some blood groups, there have been some contentious issues with the association between the ABO blood group and vulnerability to certain infectious and non - infectious diseases, recent studies and researches have suggested association between the ABO blood group and inflammation which is the primary risk factor of osteoarthritis specially knee osteoarthritis. The aim of this study was to investigate the relationship between the ABO blood group and primary or secondary osteoarthritis and the severity of primary osteoarthritis as well as the histopathologic association in a subgroup of patients. This study has the data of female as well as male patients. In this study we had some questionnaire format by which the patients were asked about their heredity, blood grouping, and socioeconomic structure etc. related problems. The study has a review of patients with osteoarthritis that served as the case group and random sampling has been done. The study was performed to investigate the expression of blood group antigens in synovial tissue of the knee in both cases and controls. A total of 200 patients who were affected by osteoarthritis of rural as well as urban locality were involved. The proportion of A and B blood group was higher percentage in female patients (20.8% and 47.9% respectively). Male patients of the blood group A and O had a higher percentage (30% and 35% respectively). This study suggested that the blood group A and B was associated with primary knee osteoarthritis, as well as its radiological severity. This study revealed that blood group A, B, AB and O were associated with osteoarthritis disease, which shed new light on the nature of osteoarthritis, and the development of new methods of therapy of osteoarthritis disease.
Keywords: Osteoarthritis, Blood group, Inflammation, Histopathology, Socioeconomic structure, Synovial tissue, Radiology
Edition: Volume 13 Issue 4, April 2024,
Pages: 128 - 130