International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

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Informative Article | Dermatology | India | Volume 13 Issue 3, March 2024 | Rating: 4.5 / 10

Undifferentiated Pleomorphic Sarcoma

Dr Madhu R | Dr Vishal V Wali | Dr Kiran S Malipatil

Abstract: Undifferentiated pleomorphic sarcoma (UPS) is a rare soft tissue sarcoma with high risk of metastasis and local recurrence. Largely affects elderly males, ultraviolet radiation has predominant etiological role, most common sites being extremities. Undifferentiated pleomorphic sarcoma closely shares similar features with atypical fibroxanthoma but deep subcutaneous invasion, lymphovascular invasion, tumor necrosis differentiates UPS from atypical fibroxanthoma. Wide excision is the gold standard treatment, chemoradiotherapy acts as adjunctives. A 63 year old male patient presented with multiple swellings over left thigh and left groin since 6months, on examination multiple well defined nodules, hard in consistency, non mobile, adherent to underlying skin, were seen over left thigh, with left sided inguinal lymphadenopathy which was non tender and hard in consistency. Histopathology and Immunochemistry features were suggestive UPS and PET scan revealed no metastasis. Patient was treated with chemoradiotherapy. Undifferentiated pleomorphic sarcoma is a diagnosis of exclusion hence this case is reported for its rarity.

Keywords: Undifferentiated pleomorphic sarcoma (UPS), Malignant fibrous histiocytoma, Pleomorphic spindle cells, Wide excision

Edition: Volume 13 Issue 3, March 2024,

Pages: 1344 - 1345

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