Immunohistochemical Characterization of Canine Lymphoma

Shailja Pandey, Yamini Verma

Abstract: Lymphomas occur by clonal expansion of lymphoid cells and have distinctive morphological and immunophenotypic features. Determination of canine lymphoma immunophenotype is useful for accurate prognosis and further therapy. The current review focus on the molecular characterization that is associated with the gene mutation that leads to protein expression causing neoplastic transformation of lymphoid cells. Further there is discussion regarding immunohistochemical characterization of lymphoma for the diagnostic point of view to identify the lympohocyte lineage for confirmatory diagnosis of lymphoma and its prognosis. In this review there is details regarding immunohistochemical markers B lymphocyte (CD79a, CD20, Pax5), and T lymphocytes (CD3).

Keywords: Lymphoma, Immunohistochemical markers, B lymphocyte, T lymphocyte