Spatial Analysis of Gene Expression: Impact of Long-Distance Running on Cellular Pathways

Lekhya Bandapalli

Abstract: This study conducts a systematic review and computational analysis of over 15 research papers to explore the impact of exhaustive endurance running on genetic and metabolic pathways. Focusing on variations in WBC counts, CK serum metabolites, cortisol levels, and gene expression among ultramarathon and marathon runners, the research identifies stress-induced genetic alterations affecting metabolic and oxidative pathways. The findings highlight temporary and permanent genetic changes, underscoring the need for further research into the complex relationship between running and genetic regulation. This work serves as a foundational reference for future investigations in sports physiology, offering valuable insights for the public, coaches, and healthcare professionals.

Keywords: running, exercise, marathon, ultramarathon, genes, biochemical pathways, health