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Research Paper | Computers in Biology and Medicine | India | Volume 13 Issue 2, February 2024
Prediction of Toxicological Mechanisms of Selected Phytochemicals in Leaf of Moringa sp. and Antidiabetic Medicines
Kaushick Mishra [2] | Soumendra Nath Talapatra [11]
Abstract: Moringa sp. is an important medicinal plant, and the leaf of this plant contains several phytochemicals, which are used for anti-diabetic agents as per traditional knowledge. The present study predicted toxicity and toxicological mechanism of selected phytochemicals of Moringa sp. and antidiabetic medicines by using ProTox-II webserver. Among 26 phytochemicals, 6 phytochemicals and 2 synthetic medicines related to Tox-21 nuclear signaling pathway and stress response pathway were predicted to know toxicological mechanisms. The results indicate that selected phytochemicals and synthetic medicines were found inactive on the different parameters, but Anthraquinone was predicted to be active for ER parameter for Tox-21 nuclear receptor pathway while Tox-21 stress response pathway revealed that all the compounds were found inactive on the different parameters, but Anthraquinone was predicted active for MMP parameter. It is concluded that these phytocompounds were found to have similar activity as Glibenclamide and Metformin like medicines. In future study, it is suggested to conduct in vivo bioassay to validate this in silico study.
Keywords: Moringa sp., In silico study, Phytochemicals, Toxicological mechanism prediction, Synthetic medicines
Edition: Volume 13 Issue 2, February 2024,
Pages: 678 - 680