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Review Papers | Physiology | Volume 13 Issue 2, February 2024 | Pages: 483 - 487 | Saudi Arabia
Serum Cystatin C Level as an Early Biomarker for Detecting Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta - Analysis Study
Abstract: There are many research addressed the importance of biomarkers for early prediction of diseases thus increasing the chance for treatment. This meta-analysis study aims to evaluate serum Cystatin C as early biomarker for predicting diabetic nephropathy in patients with type 2 diabetes. Methods: Searching on five database studies which carried out from 2019-2023. Ten studies included were analyzed using ?meta?, ?metasens? and ?diagmeta? packages. R version 4.2.2. We calculated values for serum cystatin C in DM and DM with nephropathy, cut-off value, specificity, sensitivity, the area under the curve (AUC) and Receiver operating characteristic curve (ROC). The Results showed level of cystatin C was significantly higher in DM with nephropathy group [MD = 1.22, 95% CI (-2.22,-0.23), p-value = 0.02]. The pooled data was heterogeneous (I2 = 98%, p-value
Keywords: Cystatin C, Diabetic nephropathy, meta-analysis, biomarkers
How to Cite?: Samia Saeed Alawad, Ibrahim Abdulrahim Ali, Mohammed Abd Rhaman Adris Abdallah, "Serum Cystatin C Level as an Early Biomarker for Detecting Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta - Analysis Study", Volume 13 Issue 2, February 2024, International Journal of Science and Research (IJSR), Pages: 483-487, https://www.ijsr.net/getabstract.php?paperid=SR24204165145, DOI: https://dx.doi.org/10.21275/SR24204165145