To Observe the Mean Platelet Volume and Mean Platelet Volume / Platelet Count Ratio in the Patients of Acute Ischemic Stroke

Vaidehi Mittal, S. K. Verma, Avriti Baveja, Manish Mittal

Abstract: Purpose: To observe mean platelet volume & mean platelet volume/platelet count ratio in the patients with Acute Ischemic Stroke. Methods: This is a cross sectional, single centre study, where in data about 94 patients with acute ischemic stroke diagnosed with the help of imaging NCCT head or MRI Brain admitted within 7 days of stroke, examination was done, NIHSS and modified Rankin scale was evaluated, MPV and Platelet count of the cases was recorded. Statistical significance was defined as p value <0.05. Results: Majority of the patients were >71 years of age (46.81%) and were males (69.58%).93.62 % patients had acute ischemic stroke of thrombotic type, 50.00% had right sided weakness and 44.68% had history of hypertension while 26% had history of diabetes mellitus. For assessment of disability of stroke by modified Rankin scale majority had a score of 4 (30.85%) and 52.13% had moderately severe stroke (NIHSS 11 - 20). Both MPV and MPV/PC ratio was found to be significantly higher in patients with thrombotic stroke and MPV/PC ratio was even found to be significantly associated with both modified Rankin scale and NIHSS score (p <0.05). Conclusion: MPV and MPV/PC ratio can be used as a marker for predictability of acute ischemic stroke and elevated MPV/PC ratio was found to be positively associated with modified Rankin scale and NIHSS and hence can be a marker for predicting disability and severity of stroke. Certain associations were found but further studies are needed on a larger sample size to explore more on these findings.

Keywords: National institute of health stroke scale (NIHSS), Mean Platelet volume (MPV), Mean platelet volume/Platelet count (MPV/PC)