Synthesis of Schiff Base Metal Complexes of 1-(2-hydroxy-5-methylphenyl) Ethan-1-One and Benzohydrazide, Their Characterization and Biological Studies

V. A. Sadafale

Abstract: Schiff base ligand was prepared by the condensation of 1-(2-hydroxy-5-methylphenyl) ethan-1-one and benzohydrazide, and then metal complexes of Co (II), Cu (II), Fe (III), Mn (III) and VO (IV) were synthesized. The metal complexes were characterized and investigated by physical and spectral techniques, namely, elemental analysis, melting point, conductivity, 1H NMR, IR, UV-Vis spectra. The antibacterial activity of all the compounds was screened against four bacterial pathogens, namely, E. coli, S. aureus, S. typhi and P. vulgaris. It has been found that the Schiff base and its metal complexes showed significant antimicrobial activity.

Keywords: Benzohydrazide, Schiff base, Metal complexes, Antibacterial activity