Immunohistochemical Expression E-Cadherin in the Basement Membrane of Cytotrophoblast, Syncytiotrophoblast and Blood Vessels of Placenta of Pre-Eclampsia
Abstract: Introduction: Pre - eclampsia is a severe pregnancy complication characterized by elevated blood pressure and proteinuria occurring after 20 weeks of gestation. It affects 2 - 5% of pregnancies worldwide. During early pregnancy, there is a temporary decrease in E - cadherin expression in trophoblastic cells as they invade the placenta. However, the role of E - cadherin in regulating placental vascularity remains poorly understood. This study aims to analyse the intensity and distribution of E - cadherin staining in the trophoblastic villi of healthy and pre - eclampsia placenta patients. Materials & Methods: This study was conducted in the Department of Pathology from September 2022 to December 2023. A total of 160 placenta samples were examined, consisting of 80 pre - eclampsia cases and 80 healthy controls. Immunohistochemistry was performed using antibodies against E - cadherin to evaluate its expression. The expression of E - cadherin was compared between cases and controls and correlated with clinicopathological parameters. Statistical analysis was conducted using the Chi - square test, and the mean and standard deviation were calculated. A p - value of
Keywords: Pre - eclampsia placenta, E - cadherin, Immunohistochemistry
How to Cite?: Dr. Sahiti S, Dr. Hemalatha A, Dr. Rathnamma P, "Immunohistochemical Expression E-Cadherin in the Basement Membrane of Cytotrophoblast, Syncytiotrophoblast and Blood Vessels of Placenta of Pre-Eclampsia", Volume 13 Issue 10, October 2024, International Journal of Science and Research (IJSR), Pages: 2004-2010, https://www.ijsr.net/getabstract.php?paperid=SR241028173113, DOI: https://dx.doi.org/10.21275/SR241028173113