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Review Papers | Microbiology | India | Volume 13 Issue 1, January 2024
Molecular Basis of Biofilm Production and Antibiotic Resistance in Klebsiella Species from Diabetic Ulcer
Aysha Salim [3] | Dr. Edwin Dias | Dr. Meena [16]
Abstract: Aim: The aim of this study is to investigate molecular basis of biofilm production and antibiotic resistance in Klebsiella species from diabetic ulcer. Diabetes mellitus is a chronic metabolic condition characterized by high blood glucose, often known as blood sugar. Infected wounds are a common complication among diabetics. Design and Method: A systematic literature review to identify peer-reviewed studies on molecular basis of biofilm formation and antibiotic resistance in Klebsiella species from diabetic ulcers. The inclusion criteria for the search included finding an English language article published in a peer reviewed journal that included our keywords and discussed the antibiotic resistance and molecular basis of biofilm formation of Klebsiella species from diabetic ulcer, including early works pertinent to current review. According to data published by the World Health Organization, the prevalence of diabetes mellitus has gradually increased over time. Diabetic foot ulcers are estimated to impact approximately 10%-15% of those with diabetes at some point. Bacterial strains obtained from the wounds of individuals with diabetes exhibit various types, encompassing gram-positive and gram-negative bacteria. Multidrug resistant organisms are frequent in diabetic foot ulcer patients. Biofilms may impair antibiotic penetration into the wound bed or render leukocytes ineffective by establishing antiphagocytic characteristics inside the biofilm matrix. Klebsiella species has also been identified as a major isolate in diabetic ulcers in several investigations. The goal of this study is to look at molecular characteristics of biofilm development and antibiotic resistance of Klebsiella in diabetic ulcers.
Keywords: Diabetic ulcer, Biofilm, Antibiotic resistance, Klebsiella species, Polymerase Chain Reaction
Edition: Volume 13 Issue 1, January 2024,
Pages: 948 - 955