Exploring the Neurological Impacts of Sevoflurane: A Comprehensive Review

Anju Thomas, Jeas John

Abstract: Inhalational anesthetic, sevoflurane, is commonly used as a part of general anesthesia but the neurotoxic effects of this potent gas have raised questions, especially in vulnerable groups including pediatric and elderly patients. This review centers on the processes via which exposure to sevoflurane during development may result in adverse long-term effects on the brain. This review addresses the current understanding of sevoflurane-induced neurotoxicity by discussing potential causes such as oxidative stress, neuroinflammation, death of neural cells, mitochondrial malfunction, and apoptosis.

Keywords: Sevoflurane, Neurotoxicity, Neurodegeneration, Neuroinflammation