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Research Paper | Pharmaceutical Science | India | Volume 12 Issue 11, November 2023
Formulation and Evaluation of Gastro Resistant-Colon Targeted Drug Delivery System Containing Mesalazine Tablets
K. Srinivasan | R. Suresh [41] | Dr. S. Chandra [11] | Dr. N. Senthil Kumar
Abstract: The formulation and evaluation of a gastro-resistant colon-targeted drug delivery system containing mesalazine tablets are explored in this study. Mesalazine, a medication used to treat inflammatory bowel diseases, requires targeted delivery to the colon to maximize therapeutic efficacy and minimizing the systemic side effects. To achieve this, a novel drug delivery system was developed to bypass the gastric degradation and a PH controlled drug release in the colon. The formulation involved the following steps such as formulation of mesalazine tablets by direct compression method, encapsulation of mesalazine with gastro-resistant coating using enteric coating agents Eudragit S-100 and Hydroxypropyl methylcellulose (HPMC) in various proportions thereby preventing tablets from stomach acid and enzyme degradation. The tablets were designed to release the drug in the colon, where it is needed most. The evaluation of this delivery system encompassed various parameters such as in vitro drug release studies, physicochemical characterization, and stability testing. The drug release kinetics was investigated under simulated physiological conditions to assess the targeted release profiles. Physicochemical properties of the tablets were analyzed to ensure the integrity of the formulation. Additionally, stability testing was conducted to assess the shelf-life and viability of the formulated tablets over time. The results demonstrated the successful formulation of mesalazine tablets with gastro-resistant colon-targeted drug delivery capabilities. The developed system exhibited controlled drug release patterns, ensuring sustained therapeutic levels of mesalazine in the colon. This approach has the potential to enhance treatment outcomes and minimize unwanted systemic effects associated with conventional delivery methods.
Keywords: Colon targeted drug delivery system, mesalazine gastro resistant tablets, novel drug delivery systems, direct compression tablets
Edition: Volume 12 Issue 11, November 2023,
Pages: 377 - 385