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Review Papers | Pharmaceutical Science | India | Volume 12 Issue 8, August 2023

A Review Article on Gastroretentive Drug Delivery System

Poonam Gangwar

Abstract: In recent years, gastroretentive drug delivery systems (GRDDS) have gained attention in the field of oral drug delivery systems. Oral controlled release and site-specific drug delivery systems have piqued the interest of pharmaceutical researchers seeking to improve therapeutic advantage. Gastroretentive drug delivery systems are one of these novel approaches to prolong gastric residence time, thereby targeting site-specific drug release in the stomach for local or systemic effects. Controlled-release dosage forms have been extensively used to improve therapy with several important drugs. Conventional oral dosage forms pose low bioavailability problems because of their quick gastric transition. To comprehend the various physiological challenges associated with achieving gastric retention, important factors controlling gastric retention from the stomach, especially for drugs that are less soluble in the intestine's alkaline pH. There are various gastroretentive approaches designed and developed until now, i.e., high density (sinking), floating, bio-or mucoadhesive, expandable, unfoldable, super porous hydrogel, and magnetic systems. Also, drugs that produce their local action in the stomach get quickly emptied and don?t get sufficient residence time in the stomach. The system is useful for drugs that are unstable in the intestine or have low solubility or permeability in the small intestine.

Keywords: Gastroretentive, Controlled release, Hydrogel, Mucoadhesive, Permeability

Edition: Volume 12 Issue 8, August 2023,

Pages: 2445 - 2453