Exploring Phenolic Compounds and Alpha-Glucosidase Inhibition Potential of HEDERA NEPALENSIS in the High Mountains of Northern Vietnam

Tran Chieu An ^[2] | Pham Hong Ngoc ^[2] | Phung Van Trung ^[2]

Abstract: In the high mountain regions of Vietnam, Hedera nepalensis is extensively dispersed and has been shown to have a variety of phytochemicals. This study's major goals were to identify phenolic acids and flavonoidscompounds, andevaluate ?-glucosidase inhibitory activity of H. nepalensis in the mountainous regions of four northern Vietnamese provinces, including Ha Giang, Lao Cai, Lai Chau, and Lang Son. All H. nepalensiscrude extracts were subjected to the UHPLC-Q-TOF-MS/MS technique, which was used in both the negative and positive electrospray ionization modes to identify 5 flavonoids and 6 phenolic acids. The moderate ?-glucosidase inhibitory activity of these samples was also discovered at the tested concentration.

Keywords: Hedera nepalensis, ?-glucosidase, UHPLC-Q-TOF-MS/MS, flavonoids, phenolic acids

Edition: Volume 12 Issue 8, August 2023,

Pages: 1529 - 1533