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Experimental Result Paper | Pharmacy | Turkiye | Volume 12 Issue 8, August 2023

Enhancing Skin Antioxidant Delivery and Efficacy: Evaluating Liposomal Formulations of Resveratrol, Coenzyme Q10, and Vitamin E

Aylin Ulkucu | Gulgun Yener

Abstract: This study aims to evaluate the influence of liposomes on the effective delivery of antioxidants into the skin. A liposomal cream(RSV-CoQ10-VitE-Lipo)and a non-liposomal cream (RSV-CoQ10-VitE-Cream)containing resveratrol, coenzyme Q10, vitamin E were prepared. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and encapsulation efficacy (EE) of liposomes were determined. In vitro permeation studies of the formulations were performed with porcine skin in Franz cells over 48 hours. Antioxidant activities of samples were measured with DPPH assay. RSV-CoQ10-VitE-Lipo had mean size 96.4 nm, PDI 0.292, ZP -49.7 mV, 95.375% RSV, 95.885% CoQ10, 95.683% VitE. DPPH assay results showed that RSV-CoQ10-VitE-Lipo had the highest antioxidant activity (90.36% ? 1.1).RSV-CoQ10-VitE-Lipo is an effective topical formulation for protecting skin against free radicals.

Keywords: Delivery, liposome, resveratrol, coenzyme Q10, topical

Edition: Volume 12 Issue 8, August 2023,

Pages: 988 - 993