Deubiquitinases (DUBs): A Sub - Family of Master Regulators in Modulating Inflammatory Response through Toll Like Receptor (TLR) Signalling

Venketesh K. Panda

Abstract: Inflammation is an inductive response stimulated by foreign pathogens or infection which trigger host defence machinery for the recruitment of immune components to the site. However, the mechanisms, context, and significance of inflammation throughout normal immune responses and pathology, on the other hand, is constantly evolving. Toll like receptors (TLR) are receptors on the cell surface and plays pivotal role in innate immune system. It recognizes various microbial components and induce a signalling cascade that drives the expression of inflammatory cytokines genes. In addition, DUBs play key role in modulation TLR mediated inflammatory responses and are known to be regulator of various cellular events. Studies showed that Ubiquitin specific peptidase (USP) to be involved inflammation via TLR mediated pathway. Studies regarded TLRs and USPs was not fully understood. Here we explained structure and function of both TLRs and DUBs. Also, we have highlighted the TLR mediated DUBs inflammation and their possible therapeutic targets.

Keywords: Inflammation, Toll like receptors, Deubiquitinates, Ubiquitin specific peptidase (USP), Inflammatory response