Comprehensive Analysis of Hedera Helix Leaves: Chemical Composition and its Antibacterial and Antidiabetic Potentials

Dinh Luu Nhat Quynh, Tran Chieu An, Doan Le Quynh Nhu, Tran Phan Huynh Nhu, Pham Hong Ngoc, Phung Van Trung

Abstract: This research aimed to study on chemical constituents and investigate bioactivities of Hedera helix, including antibacterial and antidiabetic. From the methanol extract of H. helix leaves collected in Da Lat province (Vietnam), four triterpene saponins were isolated and determined as ?-hederin (1), hederacoside D (2), hederacoside B (3), and hederacoside C (4). Their chemical structures were elucidated by NMR. The fractions and isolated compounds of H. helix leaves showed low antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Pseudomonas aeruginosa) bacteria. In addition, these samples were found to have low?-glucosidase inhibitory activity at tested concentration.

Keywords: Hedera helix, Staphylococcus aureus, Pseudomonas aeruginosa, ?-glucosidase, triterpene saponins

How to Cite?: Dinh Luu Nhat Quynh, Tran Chieu An, Doan Le Quynh Nhu, Tran Phan Huynh Nhu, Pham Hong Ngoc, Phung Van Trung, "Comprehensive Analysis of Hedera Helix Leaves: Chemical Composition and its Antibacterial and Antidiabetic Potentials", Volume 12 Issue 8, August 2023, International Journal of Science and Research (IJSR), Pages: 467-472, https://www.ijsr.net/getabstract.php?paperid=SR23727195358, DOI: https://dx.doi.org/10.21275/SR23727195358