Trogocytosis and Acquired PD1 Receptor in Leukemia & Its Role in Cancer Immunology

Abstract: Aim: Cancer, one of the most dreaded diseases of human beings, has always been the cynosure of researchers. Everyday, new studies are being done to know more about the tumor cell - immune cell interactions that further lead to a generation of new techniques and therapies for cancer treatment. Method: The phenomenon that has catched everyone?s eye is trogocytosis. The discovery of this unusual transfer mechanism has apprised the interest of oncologists and immunologists in cancer immunotherapy. Our study will focus on leukemia among other cancers. We will also analyze the role of ligand - receptor engagements and signaling pathways. Conclusion: In conclusion, we will review the role of trogocytosis in cancer immunology, how it inhibits immune cell responses, and its significance in non - immunological processes.

Keywords: Leukemia, Trogocytosis, PD - 1, pMHC, Fc? receptor, PI3K - AKT pathway

Edition: Volume 12 Issue 7, July 2023,

Pages: 1763 - 1766